BROCHURE
Aristidis Michael Tsatsakis  is a Professor,University of Crete,Greek

Aristidis Michael Tsatsakis

Professor

Organizing committee

Greek

University of Crete

BIOGRAPHY

Professor, Academician Aristidis Tsatsakis, PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS, FMWAS is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion.

Prof Tsatsakis has published well over 1000 works (articles in journals, books and abstracts proceedings), over 500 of them in ISI journals. He is the holder of several patents and has an extensive array of citations (over 12,000 GS) and reads /downloads (over 80,000 RG) of his papers. His current IF index is 54 (GS) and 43 (ISI).

Prof Tsatsakis has given over 200 keynote and plenary lectures in international congresses and has been the promoter and chair of numerous Symposiums and workshops in International Forum. He has coordinated as a PI in over 60 scientific research and technology projects and has established worldwide collaborations.

Prof. Tsatsakis has a long-standing activity as Editor in toxicology journals, he is currently Editor in chief of Toxicology Reports and editor of Food and Chemical Toxicology and has served as editor and guest editor in many other journals, such as Toxicology, Food and Chemical Toxicology, Toxicology Letters.

Aristides Tsatsakis was elected EUROTOX President-Elect in 2012 served as President (2014-2016) of the Federation of European Toxicologists and European Societies of Toxicology. Prof. Tsatsakis is Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014), Doctor Honorary Causa of the Mendeleev Moscow University (2016), of the Far East Federal University (FEFU), Vladivostok 2017 and of the Carol Davila, in Bucharest (2017). In 2016 he was elected Foreign Member of the National Academy of Sciences of Russia (FMRAS), in 2017 Foreign Member of Fellow Academy of Toxicological Sciences (FATS, USA) and in 2018 Full Member of The World Academy of Sciences (FMWAS). In 2017 he was elected Honorary Member of Bulgarian Toxicology Society and in 2018 Honorary President of the European Institute of Nutritional Medicine (E.I.Nu.M.) and Honorary Member of EUROTOX.

Aristides Tsatsakis is also the inspirator, founder and chief scientific leader of the University of Crete spin-off Company ToxPlus S.A. The main research interests of Professor Tsatsakis include biomonitoring and risk assessments of xenobiotics as well as links of chronic exposure to them at low doses with health problems and diseases. He developed numerous biomarkers of exposure and of effects for various chemicals, in particular pesticides, pharmaceuticals, etc., uncovering the mechanistic understanding of the mode of action and adverse outcome pathways leading to clinical effects and chronic diseases (metabolic, autoimmune, cancer etc.)

Professor Tsatsakis’ long-standing public activities in disseminating science for safety health and wellbeing of the society and the environment have often been endorsed and awarded by state and municipal authorities. His motivation and basic concept highlights the important role of academia involvement in social life problems. The postulation of real-life risks simulation based on low dose combined long term exposures related to health issues, is a crucial element and the central driving force for application of theory to practice on safety evaluations in 21 century. 

PUBLICATIONS

1. Katsikantami I., Colosio C., Alegakis A., Tzatzarakis M.N., Vakonaki E., Rizos A.K., Sarigiannis D.A., Tsatsakis, A.M. (2019). Estimation of daily intake and risk assessment of organophosphorus pesticides based on biomonitoring data – The internal exposure approach. Food Chem. Toxicol, 123, 57–71.

2. Kouretas D., Tsatsakis A., Poulas K. (2018). Editorial: Alternative tobacco products: Toxicology and health issues. Food Chem. Toxicol. 118, 523–525.  

3. Buha A., Matovic V., Antonijevic B., Bulat Z., Curcic M., Renieri E. A., Tsatsakis A.M., Schweitzer A., Wallace D. (2018). Overview of cadmium thyroid disrupting effects and mechanisms. Int. J. Mol. Sci. 19(5).  

4. Imtiaz M., Mushtaq M.A., Nawaz M.A., Ashraf M., Rizwan M.S., Mehmood S., Aziz O., Rizwan M., Virk M.S., Shakeel Q., Ijaz R., Androutsopoulos V.P., Tsatsakis A.M., Coleman M.D. (2018). Physiological and anthocyanin biosynthesis genes response induced by vanadium stress in mustard genotypes with distinct photosynthetic activity. Environ. Toxicol. Pharmacol. 62, 20–29.  

5. Docea A.O., Gofita E., Goumenou M., Calina D., Rogoveanu O., Varut M., Olaru C., Kerasioti E., Fountoucidou P., Taitzoglou I., Zlatian O., Rakitskii V.N., Hernandez A.F., Kouretas D., Tsatsakis A. (2018) Six months exposure to a real life mixture of 13 chemicals’ below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats, Food Chem. Toxicol. 115 470–481.  

6. Veremchuk, L. V., Tsarouhas, K., Vitkina, T. I., Mineeva, E. E., Gvozdenko, T. A., Antonyuk, M. V., Rakitskii, V.N., Sidletskaya, C.A., Tsatsakis, A.M., Golokhvast, K. S. (2018). Impact evaluation of environmental factors on respiratory function of asthma patients living in urban territory. Environ.Pol. 235, 489–496.  

7. Surichan S., Arroo R.R., Ruparelia K., Tsatsakis A.M., Androutsopoulos V.P. (2018) Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes, Food Chem. Toxicol. 113 228–235.

8. Coricovac DE, Moacă EA, Pinzaru I, Cîtu C, Soica C, Mihali CV, Păcurariu C, Tutelyan VA, Tsatsakis A, Dehelean CA. Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile. Front Pharmacol. 2017 Mar 28;8:154 – IF 4.418

9. Mioc M, Soica C, Bercean V, Avram S, Balan-Porcarasu M, Coricovac D, Ghiulai R, Muntean D, Andrica F, Dehelean C, Spandidos DA, Tsatsakis AM, Kurunczi L. Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity. Int J Oncol. 2017 Mar 14 – IF 3.018

10. Tsatsakis AM, Nawaz MA, Kouretas D, Balias G, Savolainen K, Tutelyan VA, Golokhvast KS, Lee JD, Yang SH, Chung G. Environmental impacts of genetically modified plants: A review. Environ Res. 2017 Mar 27 – IF 3.088

10. Tzatzarakis MN, Vakonaki E, Moti S, Alegakis A, Tsitsimpikou C, Tsakiris I, Goumenou M, Nosyrev AE, Rizos AK, Tsatsakis AM. Quantification of 4-Methylimidazole in soft drinks, sauces and vinegars of Greek market using two liquid chromatography techniques. Food ChemToxicol. 2017 Mar 19. . pii: S0278-6915(17)30122-9 – IF 3.584

11. Alamolhodaei NS, Tsatsakis AM, Ramezani M, Hayes AW, Karimi G. Resveratrol as MDR reversion molecule in breast cancer: An overview. Food ChemToxicol. 2017 May;103:223-232 - IF 3.584

12. Hernández AF, Tsatsakis AM. Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment. Food ChemToxicol. 2017 May;103:188-193 -IF 3.584

13. Vinceti M, Violi F, Tzatzarakis M, Mandrioli J, Malagoli C, Hatch EE, Fini N, Fasano A, Rakitskii VN, Kalantzi OI, Tsatsakis A. Pesticides, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a case-control study. Environ Res. 2017 May;155:261-267 - IF 3.088

14. Nedelescu M, Baconi D, Neagoe A, Iordache V, Stan M, Constantinescu P, Ciobanu AM, Vardavas AI, Vinceti M, Tsatsakis AM. Environmental metal contamination and health impact assessment in two industrial regions of Romania.Sci Total Environ. 2017 Feb 15;580:984-995 – IF 3.976

15. Kuskov AN, Kulikov PP, Goryachaya AV, Tzatzarakis MN, Docea AO, Velonia K, Shtilman MI, Tsatsakis AM. Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study. Nanomedicine. 2017 Apr;13(3):1021-1030 –IF 5.671

16. Zakharenko AM, Engin AB, Chernyshev VV, Chaika VV, Ugay SM, Rezaee R, Karimi G, Drozd VA, Nikitina AV, Solomennik SF, Kudryavkina OR, Xin L, Wenpeng Y, Tzatzarakis M, Tsatsakis AM, Golokhvast KS. Basophil mediated pro-allergic inflammation in vehicle-emitted particles exposure. Environ Res. 2017 Jan;152:308314 - IF 3.088

17. Katsikantami I, Sifakis S, Tzatzarakis MN, Vakonaki E, Kalantzi OI, Tsatsakis AM, Rizos AK. A global assessment of phthalates burden and related links to health effects. Environ Int. 2016 Dec;97:212-236 – IF 5.929

18. Neagu M, Constantin C, Tampa M, Matei C, Lupu A, Manole E, Ion RM, Fenga C, Tsatsakis AM. Toxicological and efficacy assessment of post-transition metal (Indium) phthalocyanine for photodynamic therapy in neuroblastoma. Oncotarget. 2016 Oct 25;7(43):69718-69732 – IF 5.008

19. Kuskov AN, Kulikov PP, Shtilman MI, Rakitskii VN, Tsatsakis AM. Amphiphilic poly-Nvynilpyrrolidone nanoparticles: Cytotoxicity and acute toxicity study. Food ChemToxicol. 2016 Oct;96:273-9 - IF 3.584

20. Tsatsakis AM, Docea AO, Tsitsimpikou C. New challenges in risk assessment of chemicals when simulating real exposure scenarios; simultaneous multi-chemicals' low dose exposure. Food ChemToxicol. 2016 Oct;96:174-6 - IF 3.584

21. Negrei C, Hudita A, Ginghina O, Galateanu B, Voicu SN, Stan M, Costache M, Fenga C, Drakoulis N, Tsatsakis AM. Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment. Front Pharmacol. 2016 Jun 23;7:172 - IF 4.418

22. Neagu M, Piperigkou Z, Karamanou K, Engin AB, Docea AO, Constantin C, Negrei C, Nikitovic D, Tsatsakis A. Protein bio-corona: critical issue in immune nanotoxicology. Arch Toxicol. 2017 Mar;91(3):1031-1048 – IF 6.637

23. Dehelean CA, Soica C, Pinzaru I, Coricovac D, Danciu C, Pavel I, Borcan F, Spandidos DA, Tsatsakis AM, Baderca F. Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma. Food ChemToxicol. 2016 Sep;95:149-58 - IF 3.584

24. Tsitsimpikou C, Vasilaki F, Tsarouhas K, Fragkiadaki P, Tzardi M, Goutzourelas N, Nepka C, Kalogeraki A, Heretis I, Epitropaki Z, Kouretas D, Tsatsakis AM. Nephrotoxicity in rabbits after long-term nandrolonedecanoate administration. Toxicol Lett. 2016 Sep 30;259:21-7 –IF 3.522

25. Wilks MF, Blaauboer BJ, Schulte-Hermann R, Wallace HM, Galli CL, Haag-Grönlund M, Matović V, Teixeira JP, Zilliacus J, Basaran N, Bonefeld-Jørgensen EC, Bourrinet P, Brueller W, Claude N, Miranda JP, Gundert-Remy U, Håkansson H, Kovatsi L, Liesivuori J, Lindeman B, Lison D, Leconte I, Martínez-López E, Murias M, Michel C, Scheepers PT, Stanley L, Tsatsakis A. The European Registered Toxicologist (ERT): Current status and prospects for advancement. Toxicol Lett. 2016 Sep 30;259:151-5 - IF 3.522

26. Vardavas AI, Stivaktakis PD, Tzatzarakis MN, Fragkiadaki P, Vasilaki F, Tzardi M, Datseri G, Tsiaoussis J, Alegakis AK, Tsitsimpikou C, Rakitskii VN, Carvalho F, Tsatsakis AM. Long-term exposure to cypermethrin and piperonylbutoxide cause liver and kidney inflammation and induce genotoxicity in New Zealand white male rabbits. Food ChemToxicol. 2016 Aug;94:250-9 - IF 3.584

27. Wallace H, Roberts R, Corsini E, Bonefeld-Jorgensen E, Orhan H, Mach M, Weiser T, Carvalho F, Iscan M, Tsatsakis A. Toxicology as an academic discipline in European Universities. Toxicol Lett. 2016 Jul 8;254:63 - IF 3.522

28. Galateanu B, Hudita A, Negrei C, Ion RM, Costache M, Stan M, Nikitovic D, Hayes AW, Spandidos DA, Tsatsakis AM, Ginghina O. Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response. Int JOncol. 2016 Jun;48(6):2295-302 - IF 3.018

29. Piperigkou Z, Karamanou K, Engin AB, Gialeli C, Docea AO, Vynios DH, Pavão MS, Golokhvast KS, Shtilman MI, Argiris A, Shishatskaya E, Tsatsakis AM. Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics. Food ChemToxicol. 2016 May;91:42-57 - IF 3.584

30. Stivaktakis PD, Kavvalakis MP, Tzatzarakis MN, Alegakis AK, Panagiotakis MN, Fragkiadaki P, Vakonaki E, Ozcagli E, Hayes WA, Rakitskii VN, Tsatsakis AM. Longterm exposure of rabbits to imidaclorpid as quantified in blood induces genotoxic effect. Chemosphere. 2016 Apr;149:108-13 – IF 3.698

31. Ozcagli E, Alpertunga B, Fenga C, Berktas M, Tsitsimpikou C, Wilks MF, Tsatsakis ΑM. Effects of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites on DNA damage and repair under in vitro conditions. Food ChemToxicol. 2016 Mar;89:1-7 - IF 3.584

32. Nitulescu GM, Margina D, Juzenas P, Peng Q, Olaru OT, Saloustros E, Fenga C, Spandidos DΑ, Libra M, Tsatsakis AM. Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review). Int J Oncol. 2016 Mar;48(3):869-85 - IF 3.018

33. Vasilaki F, Tsitsimpikou C, Tsarouhas K, Germanakis I, Tzardi M, Kavvalakis M, Ozcagli E, Kouretas D, Tsatsakis AM. Cardiotoxicity in rabbits after long-term nandrolonedecanoate administration. Toxicol Lett. 2016 Jan 22;241:143-51 -IF 3.522

34. Piperigkou Z, Karamanou K, Afratis NA, Bouris P, Gialeli C, Belmiro CL, Pavão MS, Vynios DH, Tsatsakis AM. Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules. Toxicol Lett. 2016 Jan 5;240(1):32-42 -IF 3.522

35. Margină D, Ilie M, Grădinaru D, Androutsopoulos VP, Kouretas D, Tsatsakis AM. Natural products-friends or foes? Toxicol Lett. 2015 Aug 5;236(3):154-67 - IF 3.522

36. Nikitovic D, Tzardi M, Berdiaki A, Tsatsakis A, Tzanakakis GN. Cancer microenvironment and inflammation: role of hyaluronan. Front Immunol. 2015 Apr 14;6:169 – IF 5.695

37. Tzatzarakis MN, Vakonaki E, Kavvalakis MP, Barmpas M, Kokkinakis EN, Xenos K, Tsatsakis AM. Biomonitoring of bisphenol A in hair of Greek population. Chemosphere. 2015Jan;118:336-41 – IF 3.698

38. Golokhvast K, Vitkina T, Gvozdenko T, Kolosov V, Yankova V, Kondratieva E, Gorkavaya A, Nazarenko A, Chaika V, Romanova T, Karabtsov A, Perelman J, Kiku P, Tsatsakis A. Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy City/Industrial Seaport Residents. Oxid Med Cell Longev. 2015;2015:412173 – IF 4.492

39. Wilks MF, Tsatsakis AM. Environmental contaminants and target organ toxicities - new insights into old problems. Toxicol Lett. 2014 Oct 15;230(2):81-4 - IF 3.522

40. Nikitovic D, Juranek I, Wilks MF, Tzardi M, Tsatsakis A, Tzanakakis GN. Anthracycline-dependent cardiotoxicity and extracellular matrix remodeling. Chest. 2014 Oct;146(4):1123-30 – IF 6.136

41. Kerasioti E, Stagos D, Priftis A, Aivazidis S, Tsatsakis AM, Hayes AW, Kouretas D. Antioxidant effects of whey protein on muscle C2C12 cells. Food Chem. 2014 Jul 15;155:271-8 – IF 4.052

42. Kokkinaki A, Kokkinakis M, Kavvalakis MP, Tzatzarakis MN, Alegakis AK, Maravgakis G, Babatsikou F, Fragkiadakis GA, Tsatsakis AM. Biomonitoring of dialkylphosphate metabolites (DAPs) in urine and hair samples of sprayers and rural residents of Crete, Greece. Environ Res. 2014 Oct;134:181-7 – IF 3.088

43. Kavvalakis MP, Tzatzarakis MN, Theodoropoulou EP, Barbounis EG, Tsakalof AK, Tsatsakis AM. Development and application of LC–APCI–MS method for biomonitoring of animal and human exposure to imidacloprid. Chemosphere. 2013 Nov;93(10):2612-20 – IF 3.698

44. Juránek I, Nikitovic D, Kouretas D, Hayes AW, Tsatsakis AM. Biological importance of reactive oxygen species in relation to difficulties of treating pathologies involving oxidative stress by exogenous antioxidants. Food ChemToxicol. 2013 Nov;61:240-7 - IF 3.584

45. Androutsopoulos VP, Tsatsakis AM. Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism. ToxicolLett. 2014 Oct 15;230(2):304-13 -IF 3.522

46. Corsini E, Galbiati V, Nikitovic D, Tsatsakis AM. Role of oxidative stress in chemical allergens induced skin cells activation. Food ChemToxicol. 2013 Nov;61:74-81 - IF 3.584

47. Tsakiris IN, Tzatzarakis MN, Alegakis AK, Vlachou MI, Renieri EA, Tsatsakis AM. Risk assessment scenarios of children's exposure to aflatoxin M1 residues in different milk types from the Greek market. Food ChemToxicol. 2013 Jun;56:261-5 - IF 3.584

48. Nikitovic D, Berdiaki A, Banos A, Tsatsakis A, Karamanos NK, Tzanakakis GN. Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma? Curr Med Chem. 2013;20(23):2868-80 – IF 3.455

49. Colosio C, Alegakis AK, Tsatsakis AM. Emerging health issues from chronic pesticide exposure: innovative methodologies and effects on molecular cell and tissue level. Toxicology. 2013 May 10;307:1-2 – IF 3.817

50. Chalkiadaki G, Nikitovic D, Katonis P, Berdiaki A, Tsatsakis A, Kotsikogianni I, Karamanos NK, Tzanakakis GN. Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes. Cancer Lett. 2011 Dec 22;312(2):235-44 – IF 5.992

51. Androutsopoulos VP, Kanavouras K, Tsatsakis AM. Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases. ToxicolApplPharmacol. 2011 Nov 1;256(3):418-24 – IF 3.847

52. Kanavouras K, Tzatzarakis MN, Mastorodemos V, Plaitakis A, Tsatsakis AM. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood.ToxicolApplPharmacol. 2011 Nov 1;256(3):399-404 - IF 3.847

53. Androutsopoulos VP, Ruparelia KC, Papakyriakou A, Filippakis H, Tsatsakis AM, Spandidos DA. Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency. Eur J Med Chem. 2011 Jun;46(6):2586-95 – IF 3.902

54. Tsakirakis A, Kasiotis KM, Arapaki N, Charistou A, Tsatsakis A, Glass CR, Machera K. Determination of operator exposure levels to insecticide during bait applications in olive trees: study of coverall performance and duration of application. Int J Hyg Environ Health. 2011 Jan;214(1):71-8 – IF 3.98

55. Vardavas CI, Plada M, Tzatzarakis M, Marcos A, Warnberg J, Gomez-Martinez S, Breidenassel C, Gonzalez-Gross M, Tsatsakis AM, Saris WH, Moreno LA, Kafatos AG; HELENA Heraklion Study Group. Passive smoking alters circulating naïve/memory lymphocyte T-cell subpopulations in children. Pediatr AllergyImmunol. 2010 Dec;21(8):1171-8 – IF 3.947

56. Zafiropoulos A, Linardakis M, Jansen EH, Tsatsakis AM, Kafatos A, Tzanakakis GN.Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue. J Lipid Res. 2010 Jul;51(7):1991-2000 – IF 4.368

57. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Tsatsakis AM, Spandidos DA. Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes. PharmacolTher. 2010 Apr;126(1):9-20 – IF 11 

58. Flouris AD, Vardavas CI, Metsios GS, Tsatsakis AM, Koutedakis Y. Biological evidence for the acute health effects of secondhand smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L3-L12 – IF 4.721

59. Berdiaki A, Nikitovic D, Tsatsakis A, Katonis P, Karamanos NK, Tzanakakis GN. bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.BiochimBiophysActa. 2009 Oct;1790(10):1258-65 – IF 5.083

60. Flouris AD, Metsios GS, Carrillo AE, Jamurtas AZ, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. Acute and short-term effects of secondhand smoke on lung function and cytokine production. Am J RespirCrit Care Med. 2009 Jun 1;179(11):1029-33 – IF 13.118

61. Zafiropoulos A, Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN. Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells.Mol Cancer Res. 2008 May;6(5):785-94 – IF 4.51

62. Berdiaki A, Zafiropoulos A, Fthenou E, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN. Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines.BiochimBiophysActa. 2008 Feb;1780(2):194-202 – IF 5.083

63. Metsios GS, Flouris AD, Jamurtas AZ, Carrillo AE, Kouretas D, Germenis AE, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. A brief exposure to moderate passive smoke increases metabolism and thyroid hormone secretion. J ClinEndocrinolMetab. 2007 Jan;92(1):208-11 – IF 5.531

64. Liapakis IE, Kottakis I, Tzatzarakis MN, Tsatsakis AM, Pitiakoudis MS, Ypsilantis P, Light RW, Simopoulos CE, Bouros DE. Penetration of newer quinolones in the empyema fluid.EurRespir J. 2004 Sep;24(3):466-70 – IF 8.332

65. Hatzidakis GI, Tsatsakis AM, Krambovitis EK, Spyros A, Eremin SA. Use of L-lysine fluorescence derivatives as tracers to enhance the performance of polarization fluoroimmunoassays. A study using two herbicides as model antigens. Anal Chem. 2002 Jun 1;74(11):2513-21 – IF 5.886

66. Torchilin VP, Levchenko TS, Whiteman KR, Yaroslavov AA, Tsatsakis AM, Rizos AK, Michailova EV, Shtilman MI. Amphiphilic poly-N-vinylpyrrolidones: synthesis, properties and liposome surface modification. Biomaterials. 2001 Nov;22(22):303544 – IF 8.387

67. Dolapsakis G, Vlachonikolis IG, Varveris C, Tsatsakis AM. Mammographic findings and occupational exposure to pesticides currently in use on Crete. Eur J Cancer. 2001 Aug;37(12):1531-6 – IF 6.163

68. Kokori H, Giannakopoulou C, Paspalaki P, Tsatsakis A, Sbyrakis S. An anaemic infant in a coma. Lancet. 1998 Jul 25;352(9124):284 – IF 44.002 

Books

1. Goumenou M, Axiotis D, Trantallidi M, Vynias D, Tsakiris I, Alegakis A, Dumanov J, Tsatsakis A. Chapter 8 “Toxicological Effects, Risk Assessment and Legislation for Aflatoxins” IN: Aflatoxins: Food Sources, Occurrence and Toxicological Effects Editors: Adina G. Faulkner, NOVA Science Publishers, 2014. pp,191-232 ISBN: 978-163117-298-4

2. Tsakiris IN, Renieri EM, Vlachou M, Theodoropoulou E, Goumenou M, Tsatsakis AM. Chapter 9 “Food Sources and Occurrence of Aflatoxins: The Experience in Greece” IN: Aflatoxins: Food Sources, Occurrence and Toxicological Effects Editors: Adina G. Faulkner, NOVA Science Publishers, 2014. pp,233-258 ISBN: 978-1-63117-298-4

3. Michalakis M, Heretis G, Chrysos E, Tsatsakis AM. Pesticides Exposure and Risk of Hypospadias. In: Pesticides.The Impacts of Pesticides Exposure, INTECH open access publisher, ISBN: 978-953-307-531-0, Viena,  2011, pp

4. Mitliang P, Tsakiris I, Tutudaki M, Tsatsakis AM. A Risk Assessment Study of Greek Population Dietary Chronic Exposure to Pesticide Residues in Fruits, Vegetables and Olive Oil. The Impacts of Pesticides Exposure, INTECH open access publisher, ISBN: 978-953-307-531-0, Viena,  2011, pp

5. Tsatsakis AM, Sifakis S, Mparmpas M, Heretis G. Pesticide Exposure and Health Related Issues in Male and Female Reproductive System. Pesticides. Formulations, Effects, Fate. ISBN: 978-953-307-532-7, Viena,  2011, pp

6. Tsatsakis A.M., Toutoudaki M., Tzatzarakis M. Assessimg Chronic Exposure to Anti
cholinesterase Pesticides by Hair Analysis. In: Science Against Terrorism, NATO ARW, edsDishovsky C., Pivovarof A., publisher Springer Verlag, 2009, chapter 2,pp 203-213.

7. Tsatsakis  A.M., Tsakiris I.N. FenthionDimethoate and Other Pesticides in Olive Oils of Organic and Conventional Cultivation. In: Olives and Olive Oil in Health and Disease Prevention, ed. Bolger E, Life Sciences, Elsevier, San Diego, CA, 2009, pp415414

8. Tsatsakis A.M., Shtilman M.I. (1992) Phytoactive polymers. New synthetic plant growth regulators. In:. Proceedings Plant Morphogenesis: Molecular approaches K.A. Roubelakis- Angelakis and K. Tran Thanh Van, eds, Plenum Publ. Co, NATO ASI series, Ser A, Life sciences, v. 253 pp. 255-272 

Selected Proceedings and Abstracts

1. M.N. Tzatzarakis, C. Girvalaki, A. Vardavas, P. Stivaktakis, A. Nosyrev, G. Leon, A.M. Tsatsakis, C. Vardavas. Evaluation of e-cigarette liquid on labeling, packaging and technical features prior the adoption of the Tobacco Products Directive (TPD) in multiple European countries. Toxicol. Lett. 295 (2018) S261. doi: 10.1016/j.toxlet.2018.06.1056.

2. Liesivuori J., A.M. Tsatsakis. Introduction to Social Toxicology. Toxicol. Lett. 295 (2018) S51. doi: 10.1016/j.toxlet.2018.06.1198.

3. I. Katsikantami, V. Karzi, M. Tzatzarakis, E. Vakonaki, A. Stavroulaki, P. Xezonaki, S. Sifakis, A.M. Tsatsakis, A. Rizos. Phenolic endocrine disruptors’ concentration levels in hair of Greek pregnant women. Toxicol. Lett. 280 (2017) S248. doi: 10.1016/j.toxlet.2017.07.687.

4. I. Fragiadoulaki, P. Stivaktakis, A. Kalogeraki, I. Tsiaousis, A. Kalliantasi, A. Stratidakis, V. Karzi, C. Mamoulakis, A. Tsatsakis.  Micronuclei frequency and blood cell number in a rabbit contrast-induced nephrotoxicity model with antioxidants as a preventive strategy. Toxicol. Lett. 280 (2017) S125. doi: 10.1016/j.toxlet.2017.07.346.

5. P. Apalaki, A. Kalliantasi, T. Nikolouzakis, I. Fragkiadoulaki, P. Stivaktakis, F. Karkala, G. Vaki, J. Tsiaoussis, A. Tsatsakis. The frequency of micronuclei, subsequent to administration of chemotherapeutic medicines in colon and rectal cancer. Toxicol. Lett. 280 (2017) S126. doi: 10.1016/j.toxlet.2017.07.348.

6. A.I. Vardavas, E. Ozcagli, P. Fragkiadaki, P.D. Stivaktakis, M.N. Tzatzarakis, K. Kaloudis, M. Tsardi, G. Datseri, J. Tsiaoussis, C. Tsitsimpikou, F. Carvalho, A.M. Tsatsakis, DNA damage after long-term exposure of rabbits to Imidacloprid and sodium tungstate, Toxicol. Lett. 258 (2016) S247–S248. doi: 10.1016/j.toxlet.2016.06.1878.

7. M.A. Tsatsakis, Biomonitoring of pesticides exposure for linking to diseases: The current status, problems and future needs, Toxicol. Lett. 259 (2016) S27–S28. doi: 10.1016/j.toxlet.2016.07.638.

8. M. Tzatzarakis, V. Karzi, E. Vakonaki, E. Barbounis, C. Tsitsimpikou, A.I. Vardavas, I. Tsakiris, S. Psycharakis, A.K. Rizos, A.M. Tsatsakis, Bisphenol A in beverages and canned foods of the Greek market, Toxicol. Lett. 238 (2015) S81. doi:10.1016/j.toxlet.2015.08.275.

9. M. Tzatzarakis, E. Vakonaki, C. Kampouropoulou, P.D. Stivaktakis, S. Papachristou, D. Vynias, I. Tsakiris, A.K. Rizos, A.M. Tsatsakis, Determination of diacetyl in butters and margarines by gas chromatography–mass spectrometry, Toxicol. Lett. 238 (2015) S81–S82. doi: 10.1016/j.toxlet.2015.08.276.

10. I. Tsakiris, M. Tzatzarakis, A. Alegakis, P. Mitlianga, E. Vakonaki, I. Tsatsakis, J. Dumanov, D. Sarigiannis, A. Tsatsakis, Monitoring of Ochratoxin A residues in Greek bottled wine, Toxicol. Lett. 238 (2015) S82–S83. doi: 10.1016/j.toxlet.2015.08.278.

11. M. Tzatzarakis, E. Vakonaki, M. Kavvalakis, P. Stivaktakis, I. Heretis, E. Barbounis, A. Vardavas, M. Barmpas, A. Tsatsakis, Development and validation of an LC–APCI-MS method for the determination of bisphenol A in hair samples of Greek population, Toxicol. Lett. 229 (2014). doi:10.1016/j.toxlet.2014.06.761.

12. M. Kavvalakis, M. Tzatzarakis, P. Stivaktakis, A. Bariotaki, A. Tsakalof, A. Vardavas, F. Babatsikou, D. Vynias, A. Tsatsakis, Imidacloprid and 6-chloronicotinic acid determination in blood serum of long-term exposed rabbits using LC–APCI-MS technique, Toxicol. Lett. 229 (2014) S227. doi:10.1016/j.toxlet.2014.06.760.

13. I. Tsakiris, M. Tzatzarakis, A. Alegakis, P. Mitlianga, M. Kavvalakis, E. Vakonaki, M. Goumenou, P. Stivaktakis, A. Tsatsakis, Monitoring of pesticides residues in Greek bottled wine, Toxicol. Lett. 229 (2014) S184. doi:10.1016/j.toxlet.2014.06.628.

14. F. Persefoni, T. Christina, V. Fotini, S. Polychronis, S. John, T. Konstantinos, T. Maria, K. Demetrios, T. Aristidis, Histopathological findings, telomerase activity and oxidative stress in kidney tissue after long-term rabbits exposure to turinabol and methanabol, Toxicol. Lett. 221 (2013).

15. M. Tzatzarakis, V. Morozova, E. Vakonaki, S. Petrochenko, M. Myagkova, E. Barbounis, A. Kanaki, S. Belivanis, A. Tsatsakis, Detection of antibodies in serum of drug users after an abstinence period of opiates use, Toxicol. Lett. 211 (2012) S152. doi:10.1016/j.toxlet.2012.03.552.

16. M. Tzatzarakis, M. Savvopoulos, M. Kavvalakis, I. Nagaev, L. Kovatsi, S. Belivanis, E. Koutras, I. Nestoros, A. Tsatsakis, Comparative evaluation of deposition of cannabinoids, opiates and cocaine in hair samples from different anatomical sites, Toxicol. Lett. 211 (2012). doi:10.1016/j.toxlet.2012.03.304.

17. P. Stivaktakis, G. Maravgakis, M. Kavvalakis, M. Tzatzarakis, A. Alegakis, E. Theodoropoulou, M. Kokkinakis, J. Liesivuori, A. Tsatsakis, Micronucleus assay in rabbits: A genotoxicity study of sub-acute levels of imidacloprid, Toxicol. Lett. 211 (2012) S67. doi:10.1016/j.toxlet.2012.03.263.

18. M. Chorti, K. Poulianiti, A. Jamurtas, K. Kostikas, M. Tzatzarakis, D. Vynias, Y. Koutedakis, A. Flouris, A. Tsatsakis, Effects of active and passive electronic and tobacco cigarette smoking on lung function, Toxicol. Lett. 211 (2012). doi:10.1016/j.toxlet.2012.03.250.

19. I. Tsakiris, C. Dionysopoulou, M. Tzatzarakis, A. Alegakis, M. Kokkinakis, E. Theodoropoulou, P. Mitlianga, J. Liesivuori, A. Tsatsakis, Monitoring organochlorine metabolites in dietary milk and estimation of hazard index values, Toxicol. Lett. 211 (2012) S96–S97. doi:10.1016/j.toxlet.2012.03.363.

20. S. Sifakis, A. Tsatsakis, Pesticide exposure and health related issues in male and female reproductive system. Biomarkers of exposure and effects on pregnancy. Toxicol. Lett. 205 (2011) S5. doi:10.1016/j.toxlet.2011.05.022.

21. Tsakiris, C. Favas, A. Tsatsakis, M. Kokkinakis, M. Mparbounis, A. Kokkinaki, Pesticide residue assessment of Organically Cultivated Greek Virgin Olive Oil, during 2009, Toxicol. Lett. 196 (2010) S336. doi:10.1016/j.toxlet.2010.03.1062.

22. I. Tsakiris, C. Favas, A. Tsatsakis, A. Alegkakis, P. Mitliagka, F. Papathanasiou, N. Niklis, Frequency and severity estimation of pesticide residues from organically cultivated olives and olive tree leafs in Greece, during 2008, Toxicol. Lett. 196 (2010). doi:10.1016/j.toxlet.2010.03.1063.

23. Tzatzarakis M, Tutudaki M, Dawson A, Fahim ACM, Kokkinakis M, Maravgakis G, Tsatsakis A. Detection of non specific organophosphate pesticide metabolites in human hair samples. TOXICOLOGY LETTERS, 2009, 189 SI: S162-S162.

24. A. Alegakis, A. Zafiropoulos, G. Tzanakakis, J. Liesivuori, C. Koutis, A. Tsatsakis, Associations between PON1 and CYP1A1 genetic polymorphisms and clinical findings of a Greek population exposed to pesticides, Toxicol. Lett. 189 (2009) S214– S215. doi:10.1016/j.toxlet.2009.06.557.Karamanos  

25. N, Malavaki C, Tzanakakis G, Tsatsakis A. Principles and applications of capillary electrophoresis and microchips in forensic and clinical toxicology. TOXICOLOGY LETTERS, 2009, 180: S1-S1. 

EDUCATION

2006 - D.Sc.: Biology Toxicology, Modern Toxicological and Modificational Aspects of Xenobiotics, Russian Academy of Science.

1986 - PhD: Organic Chemistry, Mendeleyev University, Moscow. Thesis: Synthesis and reactivity studies in the series of mercaptomethyl carboxy and methoxy carboxy derivatives of naphtalene. Advisor: Lisitsyn VN

1982 - MSc: Chemistry, Mendeleyev University, Moscow. Thesis: Chemical transformations and bioactivity of 2,7- and 2,6- naphthalene thio (oxy)acetic acids. Advisor: Lisitsyn VN

1980 - BSc: Chem. Engineering, Mendeleyev University of Chemistry, Moscow. 

RESEARCH INTEREST

  • Development of Analytical Methods for Testing of Drugs and Xenobiotics.
  • Human Biomonitoring
  • Monitoring and Biomonitoring of Xenobiotics in the Ecosystem
  • Chronic Exposure to Xenobiotics and Impact on Human Health and Linking to Diseases
  • Development of Macromolecular and Nano Systems for Targeting and Reducing Toxicity of Drugs
  • Telomeres Length
  • Chronic Diseases and Aging
  • Focus on Biomarkers and Modulation of Telomerase
  • Forensic and Clinical Issues of Anabolic and Drugs of Abuse.
  • Nanomedicine - Nanotoxicology 

HONORS AND AWARDS

Honors

  1. Full Member of The World Academy of Sciences (FMWAS) - 2018
  2. Honorary President, European Institute of Nutritional Medicine (E.I.Nu.M.) - 2018
  3. Honorary Member, Federation of European Toxicologists & European Societies of Toxicology (EUROTOX) - 2018
  4. Honorary Member, Bulgarian Toxicology Society - 2017
  5. Honorary Doctor Causa, Carol Davila University of Medicine and Pharmacy in Bucharest - 2017
  6. Honorary Doctor Causa, Federal Far East University, Vladivostok - 2016
  7. Honorary Doctor Causa, Mendeleev Moscow University in Russia - 2016
  8. Foreign Member of the National Russian Academy of Science, Academician RAS - 2016
  9. Emeritus Professor, Erisman Russian Federal Institute of Hygiene and Toxicology - 2014
  10. President of EUROTOX, Federation of European Societies of Toxicology - 2014-2016

Awards

  1. Diploma with Distinction (Excellency), Mendelejev University (1982).
  2. European Science Foundation Fellowships in Toxicology, (1993, 1994)
  3. Gold Metal, Eminent Scientist, Int.Research Promotion Council (IRPC) (2001)
  4. Executive and Nomination Committee member, EUROTOX (2004-2012)
  5. Advisor Int Program Chemical Safety (IPCS), WHO (2002)
  6. Merit Award BIONANOTOX Symposiums (2016)
  7. Award of Excellence, MED Solutions, International group (2016).
  8. Foreign Member of the National Russian Academy of Science, Academician RAS (2016)
  9. Emeritus President Hellenic Society of Toxicology (2017)
  10. Merit Award Greek Ministry of Agriculture (2017) 

COLLABORATIONS

Patents

1. Tsatsakis AM, Vlahakis J, Shtilman MI, Shashkova IB. New Water-soluble polymeric plant growth regulators. Hellenic Industrial Property Organisation. Patent No1001344/93, OB, Apl. Nο 920100479 (1992).

2. Tsatsakis AM, Vlachakis J, Shtilman MI, Shashkova IB. Water soluble polymeric systems of phytohormones with slow release Synthesis and application. European Patent, EPO Bulletin 94/32 Patent No 0609638A1, 10.08.94, Int. Cl. 5 A01N25/10, Apl. No 93600016.5 (1993).

3. Tsatsakis AM Shtilman MI, Lakarova E, Tsakalof AK. Controlled release drug systems: New water-soluble polymeric derivatives of indomethacine. Hellenic Industrial Property Organisation 18.11.94, OBI Patent No 1001718, 18.11.94, Apl. No 930100325, 30.07.93, Int. Cl. 5 A61K47/48 (1993).

4. Tsatsakis AM Shtilman MI, Kurumali E, Michalodimitrakis M. Pharmaceutical compositions: Bandages with immobilised sustained indomethacin formulation. Hellenic Industrial Property Organisation, OBI. Patent No 1001719, 18.11.94, Apl. No 903100326, 30.07.93, Int. Cl. 5 A61K9/70 (1993).

5. Τsatsakis Α, Τzatzarakis Μ, Shtilman MΙ, Harvalou Κ, Samonis G. New antifungal agents with prolonged action. Polymers of sorbic acid Hellenic Industrial Property Organisation, OΒΙ Patent No 1003871, No 20000100176, 25.05.2000 (2000).

6. Kuskov AN, Shtilman MI, Tsatsakis AM. Methods of preparation and pharmaceutical formulation of non water soluble biologically active compounds. Russian Patent. Apl. No 20061258442/15 19.07.06, RU 2325 151 C2, A61K 9/16, A61K 9/127 (2006/01).

7. Artiuhov AA, Shtilman MI, Tsatsakis AM. Novel macroporous hydrogel systems. Preparation, properties and applications. Russian Patent. Apl. No 2006 1234043/15 29.06.06, RU 2328 313 C2, A61L 15/22 (2006.01), A61L 15/44(2006.01) (2006/02).

8. Kuskov AN, Kulikov PP, Shtilman MI, Tzatzarakis M, Tsatsakis A. Water-compatible polymer compositions for delivery of biologically active substances. Patent application №  RU2015111098, (2015)

EDITORSHIP

  • Editor in Chief Toxicology Reports (2017)
  • Elsevier - Editor of Food Chemical Toxicology (FCT) (2013-Now)
  • Elsevier - Guest Editor of Toxicology Letters (2 special issues)
  • Elsevier  - Guest Editor  of Toxicology (1 special issue)
  • Elsevier - Guest Editor of Food Chemical Toxicology (FCT)
  • Associate Editor and member of the Editorial Boards: Archives of Toxicology, Toxicology Letters, Environmental Research, Human Experimental Toxicology, The Scientific World Journal, Pteridines, Russian Journal of Biopharmaceuticals, Journal of Alcohol and Drug Research, Journal of Rural Medicine Toxics
  • Ex Editor in Chief TOFSJ - Bentham Open